— Sungen
Effervescent Technology
Define Effervescent Tablets
As per revised definition proposed to US FDA, Effervescent tablet is a tablet intended to be dissolved or dispersed in water before administration. Effervescent tablets are uncoated tablets that generally contain acid or acid salts (Citric, tartaric, Malic acid or any other suitable acid or acid anhydride) and carbonates or bicarbonates (Sodium, potassium or any other suitable alkali metal carbonate or hydrogen carbonate), which react rapidly in the presence of water by releasing carbon dioxide. Due to liberation in CO2 gas, the dissolution of API in water as well as taste masking effect is enhanced.
Advantages Of Effervescent Technology
Pleasant Taste
Even Distribution Of Drug
Increased Liquid Intake
Alternative To Regular Drugs
Simple And Easy To Measure Doses
Increased Bioavailibility
Mechanism Of Effervescence
Effervescent Preparations May
Enhance Absorption And Speed Up
Onset Of Action By Increasing Gastric Ph, Therefore Hastening The Emptying Of Medication Into The Small Intestine. The Carbon Dioxide Bubbles May Also Help Intestinal Absorption
By Opening Up Paracellular Transport. Extreme Bioavailability Differences Of
Up To 4-fold Have Been Reported
Comparing Effervescent Tablets With Ordinary Tablets.