— Sungen

Softgel Technology

Improved Drug Absorption

Improved drug absorption is the primary reason for selection of Softgel as a dosage form.

Soft capsules are a single-unit solid dosage form, consisting of a liquid or semi-solid fill enveloped by a one piece sealed elastic outer shell.

Advantages Of Softgel Technology

Increased Rate Of Absorption

The solution-softgel approach, the shell ruptures within minutes to release the drug solution in the GI fluid; it is usually the rate of absorption.

Inreased Bioavailibility Of Drug

The solution-softgel formulation provided around three times the bioavailability of saquinavir as measured by the area under the plasma-time curve (AUC), compared to a hard shell capsule formulation.

Decreased Variability Of Plasmatic Drug

High variability in drug plasma levels is a common characteristic of drugs with low bioavailability. So less variability, high bioavailibility.

Patient Compliance And Consumer Preference

Consumers expressed their preference for softgels in terms of ease of swallowing, absence of taste and convenience.

Safety For Potent And Cytotoxic Drugs

By preparing a solution or suspension of drug, where the active component is essentially protected from the environment by the liquid, such safety concerns and associated toxicities have been significantly reduced

Dose Uniformity Of Low Dose Drug And Product Stability

Liquid dosing has been realized to avoid the difficulties of poor powder flow and hence content uniformity Preparations of liquid-filled softgel have proven beneficial to oxidative or hydrolytic degradable drugs.